Adagio Medical Holdings, Inc.

We are a medical device company focused on developing and commercializing products for the treatment of cardiac arrhythmias with our novel, proprietary, catheter-based Ultra-Low Temperature Ablation ( ULTA ) technology, formerly known as Ultra-Low Temperature Cryoablation ( ULTC ) technology. Our initial focus is on the treatment of ventricular tachycardia ( VT ). VT is a rapid, abnormal heart rhythm, or arrhythmia, that originates in the heart’s lower chambers, or ventricles, potentially leading to impaired blood flow and, if sustained, VT can be fatal. In the United States, VT-associated sudden cardiac death ( SCD ) accounts for approximately 300,000 deaths each year. Radio Frequency ( RF ) ablation catheters currently used to treat VT were primarily designed and approved for the treatment of atrial fibrillation ( AF ) and are therefore not designed to optimally treat the specifics of the ventricular anatomy and disease. As a result, VT procedures performed with current devices can be overly complex, with sub-optimal outcomes, a factor that has potentially led to limited growth in the market for VT ablations. Our clinically tested, proprietary ULTA products are purpose-built to treat patients with VT and are designed to address the unique anatomy of the ventricle and the specific needs of the VT patient.