CASTLE BIOSCIENCES INC

As used in this Annual Report on Form 10-K, unless the context indicates or otherwise requires, Castle Biosciences, the Company, we, us and our refer to Castle Biosciences, Inc., a Delaware Corporation. Overview Castle Biosciences is a molecular diagnostics company offering innovative test solutions to aid clinicians in the diagnosis and treatment of dermatologic cancers, Barrett’s esophagus ( BE ), atopic dermatitis ( AD ), uveal melanoma ( UM ). Since our inception in 2008, it has been our vision to transform disease management by keeping people first: patients, clinicians, employees and investors. This foundational strategy remains the guidepost for the direction of our company and the basis of long-term value creation. Our Testing Solutions Our tests are designed to deliver personalized information to help better inform clinical care decisions. For our core tissue-based tests, we use multi-analyte assays with algorithmic analysis ( MAAA ) to characterize an individual patient’s biology and generate clinically actionable information. Depending on the specific test, this information may be used to provide information to help guide treatment and patient management decisions including potential responsiveness to therapy and to assist in the diagnosis of a disease.