Monte Rosa Therapeutics, Inc.

Bus iness Overview We are a clinical-stage biotechnology company developing a portfolio of novel and proprietary molecular glue degraders, or MGDs. MGDs are small molecule drugs that employ the body’s natural protein destruction mechanisms to selectively degrade therapeutically relevant proteins, in effect editing the human proteome. MGDs function by inducing the engagement of an E3 ligase, such as cereblon, with defined structural features on surfaces of target proteins. These target proteins are also referred to as neosubstrates. The E3 ligase then tags the target protein for degradation by adding a molecular mark known as ubiquitin. We believe our MGDs provide significant advantages over existing therapeutic modalities, including other protein degradation approaches. We have developed a proprietary and industry leading discovery engine, called QuEEN TM (an abbreviation for Quantitative and Engineered Elimination of Neosubstrates ) to enable our unique target-centric MGD discovery and development approach and our rational design of MGD product candidates. To date, our QuEEN TM discovery engine has identified numerous proteins for potential targeting by our MGDs, including those targeted by product candidates in our pipeline. We combine our artificial intelligence or AI / machine learning or ML engines with multiple proprietary experimental tools to identify therapeutically relevant target proteins amenable to degradation by our MGDs.